栾明明博士，硕士生导师

联系方式

邮箱：luanmm@qlu.edu.cn

办公室：食工楼C517

学习及工作经历

2018.12-至今 半岛电竞app 化学与化工学院

2013.09-2018.12山东师范大学 化学化工与材料科学学院 分析化学 博士

2008.09-2013.07烟台大学文经学院 食品与生物工程系 讲师

2006.04-2008.07常熟理工学院 化学与材料工程系 讲师

2003.09-2006.04浙江大学 化学系 分析化学 硕士

1999.09-2003.07烟台大学 化学生物理工学院 应用化学 学士

研究领域

1.纳米荧光探针的设计构建及其在生物成像中的应用

2.早期肿瘤标志物和抗癌药物疗效的可视化诊断、评估

3.纳米酶的设计合成及其在生物医学的应用

主持和参与科研项目

1.国家自然科学基金青年项目，高灵敏纳米荧光探针用于动态可视化监测microRNA调控癌细胞凋亡及其在药效评估的应用（项目号21904074, 2020.01.01-2022.12.31, 25万元,结题，主持）

2.国家自然科学基金面上项目，表面与针尖增强拉曼光谱的高精度量子化学计算与人工智能预测 （项目号22073053, 2021.01.01-2024.12.31, 63万元,在研，参与）

3.国家自然科学基金面上项目，纳米载体材料对细胞的安全性评估：比率荧光纳米探针实时检测成像活性氧水平的变化,（项目号21775094, 2018.01.01-2021.12.31, 64万元,结题，参与）

4.国家自然科学基金重点项目，亚细胞结构水平上活性小分子协同调控细胞功能的荧光成像研究（项目号21535004，2016.01.01-2020.12.01，300.00万元，结题，参与）

5.国家重大科研仪器研制项目，单分子检测系统及其关键技术研究（项目号21527811，2016.01.01-2020.12.01，548.00万元，结题，参与）

发表论文

15. Mingyao Ren, Zhe Chen, Chuandong Ge, Wei Hu, Jing Xu, Limin Yang,Mingming Luan^*and Nianxing Wang^*Visualizing MiRNA Regulation of Apoptosis for Investigating the Feasibility of MiRNA-Targeted Therapy Using a Fluorescent Nanoprobe.Pharmaceutics.2022, 14, 1349. 2022-06-25

14. Mingyao Ren^†, Zhe Chen^†, Chuandong Ge, Wei Hu, Nianxing Wang, Limin Yang,Mingming Luan^*and Jing Xu^*Simultaneous Visualization of MiRNA-221 and Caspase-3 in Cancer Cells for Investigating the Feasibility of MiRNA-Targeted Therapy with a Dual-color Fluorescent Nanosensor.Biosensors.2022, 12, 444. 2022-06-23

13. Bo Liu, Ping Zhou, Kaiye Wang, Shaohua Gong,Mingming Luan, Na Li*, and Bo Tang*. Avoiding False Positive Signals: A Powerful and Reliable Au−Se Dual-Color Probe.ACS Sens.2021, 6(5), 1949–1955.

12. Ping Zhou,^aBo Liu,^aMingming Luan,^bNa Li^*aand Bo Tang^*aA fluorescence nanoprobe for detecting the effect of different oxygen and nutrient conditions on breast cancer cells migration and invasion.Biomater. Sci.,2021, 9(12), 4428-4432.

11. Chunhong Gao^a,#, Zhen Zhang^a,#, Shu Xing^a,Mingming Luan^a, Tingting Gai^a, Zhaosheng Hou^b, Tianduo Li^a, Jing Xu^a,*Self-assembled gelatin monolayer with coordinating regulation the composition, charge and wettability on the titanium surface

Surfaces and Interfaces，Volume 25, August 2021, 101281

10. Xiaonan Gao¹, Jia Li¹,Mingming Luan, Yanhua Li, Wei Pan, Na Li^*, Bo Tang^**. Real-time in situ monitoring of signal molecules’ evolution in apoptotic pathway via Au–Se bond constructed nanoprobe.Biosens. Bioelectron.2020, 147, 111755.

9.Mingming Luan, Wei Pan, Na Li*, and Bo Tang*, Real-Time in Situ Investigation of Upstream and Downstream Relationship between uPA and MMP-9 in MCF-7 and PANC-1 cells via Au-Se-Bond-Based Nanoprobe.Chem. Commun.,2019, 55, 5817-5820.

8.Mingming Luan, Jinjie Chang, Wei Pan, Yuanyuan Chen, Na Li* and Bo Tang*, Simultaneous Fluorescence Visualization of Epithelial–Mesenchymal Transition and Apoptosis Processes in Tumor Cells for Evaluating the Impact of Epithelial–Mesenchymal Transition on Drug Efficacy.Anal. Chem., 2018, 90, 10951-10957.

7.Mingming Luan, Longhai Yu, Yanhua Li, Wei Pan, Xiaonan Gao, Xiuyan Wan, Na Li* and Bo Tang*, Visualizing Breast Cancer Cell Proliferation and Invasion for Assessing Drug Efficacy with a Fluorescent Nanoprobe.Anal. Chem.,2017, 89, 10601-10607.

6.Mingming Luan, Na Li, Wei Pan, Limin Yang, Zhengze Yu and Bo Tang*, Simultaneous detection of multiple targets involved in the PI3K/AKT pathway for investigating cellular migration and invasion with a multicolor fluorescent nanoprobe.Chem. Commun.,2017, 53, 356-359.ESI高被引

5.栾明明，邬建敏，叶庆富,多次循环离子交换色谱纯化Cry1Ab蛋白及其肽质量谱图的分析.浙江大学学报, 2007, 529-532.

4. Jianmin Wu,Mingming Luan, Jiayin Zhao. Trypsin immobilization by direct adsorption on metal ion chelated macroporous chitosan-silica gel beads. InternationalJournal of Biological Macromolecules. 2006, 39, 185–191.

3.栾明明，邬建敏，溶胶凝胶膜包埋的胰蛋白酶用于高通量蛋白质肽谱分析.分析化学, 2006, 34, 1707-1710.

2.Mingming Luan, Fengna Xi, Jianmin Wu. New metal chelate affinity adsorbent for trypsin immobilization. Abstract Book of International Symposium on Biocatalysis and Bioprocess Engineering.2005, 126-127.

1. Fengna Xi, Jianmin Wu,Mingming Luan. Silica-supported macroporous chitosanbead for affinity purification of trypsin inhibitor.Chinese Chemical Letters. 2005, 16.

奖励和荣誉：

山东省高等学校科学技术奖一等奖，第四位，2019.12.23

主讲课程：

工程化学、无机化学、分析化学、仪器分析、环境监测等课程